#Post-Doc / #PhD positions: NMR studies of interactions, dynamics and function in #chaperones

The biomolecular NMR team at the Structural Biology Institute in
Grenoble, Franc (team leader Paul Schanda) has openings for
post-doctoral/PhD researchers to work on elucidating interactions and
dynamics in chaperone complexes, in a research project funded by
the European Research Council (ERC project ProtDyn2Function).

We are seeking candidates for a project that aims at characterizing
molecular interactions and dynamics in complexes of large
chaperones with unfolded/misfolded protein targets. In this project we
use the solid- as well as solution-state NMR to probe molecular
interactions between a hundreds-of-kilodalton large chaperone
complex and "client" proteins, as well as structural and dynamical
features of these complexes. The protein targets are already well
established in our hands, and existing NMR
characterizations/assignments as well as high-resolution EM data
allow rapidly focusing on the biological/biophysical questions.

We are seeking highly motivated and creative candidates with a strong
ability to work effectively and congenially with other group members.
For post-doctoral candidates, experience in biomolecular NMR
spectroscopy, as well as protein production and purification are
required. Strong background in chaperones would be an advantage,
but not required. Experience in one of the following research areas are
a strong plus: programming and data analysis (e.g. python
programming), biochemical characterization of proteins and functional
assays, spectroscopic techniques. Applications for a PhD position are
also welcome; experience in NMR spectroscopy is not mandatory for
the PhD position, and the successful candidate should be highly
motivated to learn state-of-the-art biomolecular solid-state NMR.
Experience in one of the following research areas are a strong plus:
programming and data analysis (e.g. python programming),
biochemical characterization of proteins and functional assays,
spectroscopic techniques.



The successful candidate will be part of a recently established
research team, hosted in the Structural Biology Institute (IBS), in one
of Europe´s most vibrant structural biology communities (centered
around the European Synchrotron Facility, the ILL neutron source,
EMBL Grenoble). Our group has access to brand-new NMR
equipment for both solution- and solid-state NMR in-house (2x600
MHz, 700, 850, 950 MHz with cryoprobes and fast-spinning MAS
probes), a state-of-the-art electron microscopy facility, as well as a
large panel of complementary biophysical techniques. The candidate
will benefit from extensive expertise on advanced isotope labeling,
solution- and solid-state NMR and biochemistry in the NMR group.
Grenoble is a pleasant mid-sized city located at the heart of the
French alps, with (public) transport connections to Paris (3 h), the
mediterranean and the nearby mountain resorts.

Applications, containing a detailed CV, a list of publications and a
clear statement of motivation, as well as names of 2-3 reference
persons should be sent via e-mail to paul.schanda@ibs.fr.